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Alternating Electric Field‐Assisted Matrix Nano‐Coating for High Spatial Resolution MALDI Imaging (Small Methods 3/2026)

Year: 2026

Type: article

Abstract: Inside Front Cover In article number 2500785, Li, Hao, Wang, and co-workers illustrate alternating electric field-assisted matrix nano-coating (AEFAMnC), a novel matrix deposition technique. By utilizing alternating electric-fields, it enables repetitive micro-extraction of analytes and nanoscale ultra-uniform matrix coating. This significantly boosts the in-situ enrichment of endogenous compounds on sample surfaces and the matrix-analyte co-crystallization, thereby enhancing the performance of high-resolution MALDI-MSI in spatial multi-omics, especially for single-cell studies.

Source: Small Methods

DOI: 10.1002/smtd.70408

Authors: Hua Guo, Jinming Li, Hao Hu, Liang Qin, Lulu Chen, Qichen Hao, Chenyu Yang, Ran Wu, Jie Feng, Rui Liu, Difan Chen, Wei Li, Shuyu Hao, Xiaodong Wang

Institutions: Minzu University of China, State Ethnic Affairs Commission, Capital Medical University, Beijing Tian Tan Hospital, Beijing Forestry University

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W7128589979

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