Work

Acquired Coagulation Factor XIII Deficiency With Spontaneous Splenic Rupture: A Case Report

Year: 2026

Type: article

Abstract: Coagulation factor XIII deficiency (FXIIID) is a rare hemorrhagic disease, mainly manifested as skin ecchymosis and hematoma. Because of its atypical clinical manifestations and normal results of routine coagulation test, platelet count and function, it has brought great challenges to the diagnosis. This case report introduces the diagnosis and treatment of an elderly male patient with FXIIID in detail, and aims to emphasize the necessity of detecting FXIII activity when spontaneous bleeding occurs in patients with normal routine coagulation function and platelet count. At the same time, it emphasizes the importance of etiology finding and individualized treatment and management for patients with FXIIID.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.72030

Authors: Jun Lu, Xijun Zhu

Language: English

Topic: Blood properties and coagulation

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820

Funders: University of Science and Technology of China, Ruijin Hospital