Year: 2025
Type: article
Study design: Study Protocol
Abstract: its physiological and systemic nature.The study aims to investigate whether LIFU can modulate the underlying neurobiological processes associated with NASHS, such as neurotransmitter release, hormonal balance, and inflammation.Methods: The proposed study will utilize LIFU to target specific brain regions involved in the regulation of neurotransmitter activity and hormonal responses, thereby addressing the physiological mechanisms underlying NASHS: Redefining Anxiety as NASHS: Anxiety is redefined as Neurotransmitter Activated Systemic Hormonal Surge (NASHS) to focus on its physiological aspects, including neurotransmitter imbalances, calcium ion flux, lipid accumulation, and systemic hormonal responses.This approach reframes anxiety as a condition with identifiable neurobiological markers that can be modulated using LIFU.LIFU Neuromodulation Protocol: The study will apply LIFU to key brain regions associated with anxiety and stress responses, such as the prefrontal cortex, amygdala, and hippocampus.These regions are targeted to alter the activity of neurotransmitters like glutamate, GABA, serotonin, and dopamine, which are implicated in NASHS.Study Design: Participants with NASHS (formerly diagnosed with anxiety) will undergo a series of LIFU sessions over a period of several weeks.Each session will involve focused ultrasound targeting of specific brain regions to modulate neural circuits and neurotransmitter activity.Outcomes will be measured using functional MRI (fMRI), electroencephalography (EEG), heart rate variability, cortisol levels, and self-reported NASHS severity scales.Results: It is hypothesized that LIFU therapy will lead to a significant reduction in NASHS symptoms by: Modulating Neurotransmitter Activity: LIFU may decrease excitatory neurotransmitters (e.g., glutamate) and increase inhibitory neurotransmitters (e.g., GABA), thereby stabilizing neural activity and reducing systemic hormonal surges.Balancing Hormonal Responses: By targeting brain regions that regulate the hypothalamic-pituitary-adrenal (HPA) axis, LIFU could help normalize cortisol and other stress-related hormone levels.Reducing Systemic Inflammation: LIFU's potential anti-inflammatory effects may further help reduce the physiological burden of NASHS, contributing to overall symptom reduction.Conclusions: This study proposes that Low-Intensity Focused Ultrasound (LIFU) could be a groundbreaking noninvasive treatment for Neurotransmitter Activated Systemic Hormonal Surge (NASHS), redefined from traditional anxiety.By modulating neurotransmitter release and balancing hormonal responses, LIFU offers a novel approach to addressing the physiological components of NASHS.If proven effective, this technique could lead to new therapeutic protocols that focus on physiological regulation rather than psychological interventions alone.
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7128599451
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