Work

Age-related Histological Changes in Cardiac Muscle Tissue

Year: 2026

Type: article

Abstract: Age-related changes in cardiac muscle tissue represent an important morphological basis for the development of cardiovascular diseases in the elderly. This study aims to analyze histological alterations of myocardial tissue associated with aging, with particular attention to structural, cellular, and interstitial modifications. Histological examination revealed progressive hypertrophy of cardiomyocytes, a reduction in the regenerative capacity of muscle fibers, and an increase in connective tissue components with advancing age. Additionally, age-related degeneration of myofibrils, accumulation of lipofuscin granules, and changes in nuclear morphology were observed.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18613421

Authors: Jumayeva, Shahzoda, Saidov, Shoxrullo

Institution: Tashkent State Medical University

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7128617792