A polygenic growth score and risk for large for gestational age birth weight
Year: 2026
Type: article
Study design: Observational Study
Abstract: Context Large for gestational age (LGA) birth weight is associated with both short- and long-term health consequences for offspring, and fetal genetics may contribute to risk for LGA birth weight. Objectives We evaluated the relationship between a polygenic growth score (PGS) and LGA birth weight in relation to maternal characteristics. Design A previously developed PGS for LGA birth weight was calculated using offspring DNA. We evaluated the relationship between tertiles of the PGS, maternal body mass index, and glycemia assessed by the 50-gram glucose challenge test on the risk for LGA birth weight using 1-way ANOVA and chi-squared tests as well as a regularized linear model. Participants Nulliparous individuals recruited from 8 clinical sites in the United States. Main Outcome Measures LGA birth weight. Results Infant genotype was available for 3286 individuals. A PGS in the first tertile was associated with a lower risk [adjusted odds ratio (aOR) 0.71, 95% confidence interval (CI) 0.53-0.94], and the third tertile with a higher risk (aOR 1.29, 95% CI 1.02-1.63) for LGA birth weight. The odds of LGA birth weight were highest in those with maternal body mass index (BMI) ≥35 kg/m2 and a PGS of either the second tertile (odds ratio 3.54, 95% CI 1.96-6.38) or third tertile (odds ratio 2.69, 95% CI 1.54-4.71). Conclusion A PGS may assist with identification of those fetuses at increased risk for LGA birth weight, particularly among individuals with a BMI ≥35 kg/m2.
Source: Journal of the Endocrine Society
Institutions: North Carolina State University, University of Pittsburgh, Northwestern University, University of Utah, University of Pennsylvania, University of California, Irvine, Indiana University Indianapolis, Indiana University School of Medicine, Columbia University Irving Medical Center, Columbia University
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,255
Funders: Columbia University, Indiana University, University of Pennsylvania, Northwestern University, University of Utah, University of Pittsburgh, Case Western Reserve University, National Institutes of Health, University of California, Irvine, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1154896220, Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk, Indiana Clinical and Translational Sciences Institute, G3041723298, Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk, G3203615657, Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk , Adverse Outcomes in Nulliparous Pregnancies: The Ohio Collaborative, G4085670364, G409966183, G5131427437, Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk, Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk, Prevention of Preterm Birth in high Risk Nulliparous Patients, G711945402, Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk, G7708129264, Institute for Clinical and Translational Science, G8662901, Dissecting the Genetic Etiology of Preterm Birth in Nulliparous Women
OpenAlex ID: W7128635024