Work

Fluoroscopic control of a magnetorobotic capsule for precision gastrointestinal sampling and delivery

Year: 2026

Type: article

Abstract: Untethered gastrointestinal (GI) devices for targeted diagnostics and interventions are constrained by limited capabilities for precise localization, controlled delivery, and reliable retrieval of liquid or gel-based payloads. Here, we introduce G-Bot, a magnetorobotic capsule that integrates fluoroscopic visibility, dual-regime magnetic actuation, and a low-cost, scalable design. The proposed actuation strategy enables decoupled orientation control and on-demand triggering of payload release or sampling. G-Bot provides sufficient radiographic contrast to support accurate manipulation under standard clinical C-arm. Device performance is evaluated in benchtop GI phantom models using samples spanning a range of viscosities under clinically relevant magnetic conditions, demonstrating image-guided sampling, targeted delivery, and feasibility for longitudinal GI monitoring.

Source: iScience

DOI: 10.1016/j.isci.2026.115007

Authors: Sophie Nguyen, Tuan-Anh Le, Melek Naz Guven, Carol Lu, Husnu Halid Alabay, Hakan Ceylan

Institutions: Mayo Clinic, Mayo Clinic in Arizona

Language: English

Topic: Micro and Nano Robotics

Subfield: Condensed Matter Physics

Field: Physics and Astronomy

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240