PACE-NODES: A phase III randomised trial of 5 fraction prostate stereotactic body radiotherapy (SBRT) versus 5 fraction prostate and pelvic nodal SBRT
Year: 2026
Type: article
Study design: Study Protocol
Abstract: PACE-NODES is a phase III randomised controlled trial for patients with high risk localised prostate cancer, planned for radical radiotherapy with at least 12 months of androgen deprivation therapy, and suitable for stereotactic body radiotherapy (SBRT). Patients are randomised to receive either prostate SBRT (control) or prostate and pelvic nodal SBRT. In both arms, treatment is given in 5 fractions delivered on alternate days over 2 weeks. The aim of the trial is to determine whether prostate and pelvic nodal SBRT can improve outcomes for this patient group compared to prostate SBRT. Clinical trial registration: PACE NODES is registered on ClinicalTrials.gov (NCT05613023).
Authors: Angela Pathmanathan, Suneil Jain, John Staffurth, Stephanie Brown, Stephanie Burnett, Fay H Cafferty, Ananya Choudhury, Monisha Dewan, Peter Hoskin, Ken McBride, Conor K McGarry, Elizabeth Miles, Julia Murray, Vedang Murthy, Olivia Naismith, Yee Pei Song, Isabel Syndikus, Alison Tree, Tim Ward, Emma Hall, Nicholas van As
Institutions: Royal Marsden NHS Foundation Trust, Queen's University Belfast, Velindre NHS Trust, Cardiff University, Institute of Cancer Research, University of Manchester, Belfast Health and Social Care Trust, Mount Vernon Hospital, Tata Memorial Hospital, The Christie NHS Foundation Trust, Clatterbridge Cancer Centre NHS Foundation Trust, National Cancer Research Institute
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,430
OpenAlex ID: W7128646879