Low Urine Uromodulin Levels are Associated With Interstitial Fibrosis and Tubular Atrophy in Native Kidney Biopsies

Year: 2026

Type: article

Abstract: Interstitial fibrosis and tubular atrophy (IFTA) is a critical histological feature assessed in kidney biopsies, with its severity strongly correlating with long-term clinical outcomes, including progression to end-stage kidney disease.1-3 Although kidney biopsy remains the gold standard for diagnosis and evaluating specific histological features such as IFTA, noninvasive methods to assess IFTA would be highly valuable for disease management, especially among patients with absolute or relative contraindications to biopsy.

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2026.106351

Authors: Manav C. Parikh, Heather Thiessen Philbrook, David Hu, Jack Bitzel, Jiashu Xue, Serena DSouza, Avi Z. Rosenberg, Dennis G. Moledina, Steven G. Coca, Chirag R. Parikh, Steven Menez

Institutions: Johns Hopkins University, Johns Hopkins Medicine, University of Pennsylvania, Yale University, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

OpenAlex ID: W7128677263