Work

Cell sorting models in tissue development

Year: 2026

Type: review

Abstract: In animal embryos, cell fate specification coordinates with the spatial organisation of cells into distinct domains, leading to the establishment of embryonic boundaries. Multiple hypotheses have been proposed to explain the mechanisms underlying cell sorting, focusing on differences in tissue adhesiveness, contractility, or cell motility. Here, we summarise the main mathematical models of cell sorting and review recent findings showing how these models yield new insights into the problem. Finally, we briefly comment on the limitations of each approach and the importance of identifying the key biophysical ingredients when building a model.

Source: Current Opinion in Systems Biology

DOI: 10.1016/j.coisb.2026.100572

Author: David Oriola

Institution: Universitat Politècnica de Catalunya

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,170

Funders: Ministerio de Ciencia, Innovación y Universidades, Departament d'Empresa i Coneixement, Generalitat de Catalunya, European Social Fund, Departament de Recerca i Universitats, Generalitat de Catalunya