Work

Myelomastocytic transformation in chronic myeloid leukemia: A diagnostic puzzle in two patients following treatment interruption

Year: 2026

Type: article

Abstract: Blast crisis in chronic myeloid leukemia (CML) with metachromatic granules poses a diagnostic challenge. We report two CML patients who defaulted therapy and presented in blast crisis (BC) with numerous blasts showing metachromatic granules. Flowcytometric immunophenotyping and immunohistochemistry aided in identifying immature mast cells (MC), while the absence of the KITD816V mutation helped to narrow down and support the diagnosis of myeloid BC with MC differentiation or myelomastocytic leukemia (MML). These cases emphasize the diagnostic difficulty when MML occurs in BC and highlight the need for further research and refined classification of these rare hematologic entities.

Source: Journal of Hematology and Allied Sciences

DOI: 10.25259/jhas_52_2025

Authors: Surbhi Singh, Aastha Gupta, Rahul Bhargava, Vikas Dua

Institution: Fortis Memorial Research Institute

Language: English

Topic: Mast cells and histamine

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7128697264