Work

Cardiovascular remodeling: key mechanisms and clinical implications linking sarcopenia and heart failure

Year: 2026

Type: article

Abstract: Sarcopenia and heart failure (HF) are interconnected through a bidirectional relationship in which cardiovascular remodeling serves as a critical mediator. This review examines the shared pathophysiological mechanisms-such as chronic inflammation, oxidative stress, and insulin resistance-that underlie both conditions. By integrating recent clinical and experimental evidence, we emphasize the role of cardiovascular remodeling in aggravating muscle loss in sarcopenia and cardiac dysfunction in HF. Furthermore, we discuss novel therapeutic targets directed at disrupting these common pathways. This analysis offers a unified framework for understanding the mechanistic links between sarcopenia and HF, with implications for future research and clinical strategies aimed at enhancing patient outcomes.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2026.1736824

Authors: Jinghong Yang, Xinyu Zhang, Jun Zhong

Institutions: Chongqing Medical University, The Affiliated Yongchuan Hospital of Chongqing Medical University

Language: English

Topic: Nutrition and Health in Aging

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801