Work

Positive relationship between an aggregate index of systemic inflammation and stress urinary incontinence: a nationwide cross-sectional analysis

Year: 2026

Type: article

Abstract: Background: Stress urinary incontinence (SUI) is a common pelvic floor condition causing unintentional urine leakage during activities that raise abdominal pressure. The aggregate index of systemic inflammation (AISI) is a novel inflammatory indicator where higher values indicate greater systemic inflammation. However, to date, the relationship between AISI and SUI lacks comprehensive evaluation. To fill this research gap, this study analyzed the link between the AISI and SUI in U.S. adults. Methods: Using National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2016, we analyzed data from 10,934 participants. SUI status was ascertained by questionnaire, and AISI was calculated from blood count records. The association between AISI and SUI was examined using weighted multivariate logistic regression models. Results: Q1: fully adjusted odds ratio (OR) =1.34; 95% confidence interval (CI): 1.074-1.677; P=0.01]. No statistically significant interactions were observed between AISI and other covariates in subgroup analyses (all P for interaction >0.05). Conclusions: Our analysis of U.S. adults suggests that elevated AISI is independently associated with SUI and highlights its value as a composite inflammatory marker for further research.

Source: Translational Andrology and Urology

DOI: 10.21037/tau-2025-744

Authors: Xiaozhi Xia, Dingbang Liu, Wei Wang, Tao Jin

Institutions: Sichuan University, West China Hospital of Sichuan University

Language: English

Topic: Pelvic floor disorders treatments

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Chengdu Science and Technology Bureau, National Key Research and Development Program of China