Work

NODES_INNDIANA_D5.3_Report on drug response in CIA model

Year: 2026

Type: article

Abstract: This report evaluates the therapeutic effects of CIC-39 in the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis. In vivo administration of CIC-39 (60 mg/kg for 15 days) effectively halted disease progression and significantly reduced the expression of the pro-inflammatory cytokines IL-17 and IFN-γ, key mediators of pathogenic Th17 and Th1 responses. These anti-inflammatory effects were achieved without altering immune cell differentiation or disrupting overall immune homeostasis, indicating a targeted immunomodulatory action. Collectively, the findings highlight CIC-39 as a promising candidate for further development as a selective and safe therapeutic approach for multiple sclerosis.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18620802

Author: Cappellano, Giuseppe

Institution: Università degli Studi del Piemonte Orientale “Amedeo Avogadro”

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7128710715

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