Work

Dataset for: The bladder as a target for PCB toxicity: Evidence from PCB levels, phase I metabolite levels, and cytochrome P450 expression following developmental exposure to a human-relevant PCB mixture in mice

Year: 2026

Type: dataset

Abstract: This dataset includes data from a study investigating how developmental exposure to an environmental PCB mixture, the MARBLES mix, affects mice bladder. The MARBLES mix mimics the relative composition of the 12 most abundant PCB congeners identified in the serum of pregnant women at higher risk of having a child with a neurodevelopmental disorder. We exposed mice MARBLES mix via maternal diet during gestation and lactation (vehicle, 0.1, 1, or 6 mg/kg/day). Offspring were euthanized at 6 to 7 weeks of age. PCBs and hydroxylated PCBs (OH-PCBs) levels were quantified in bladder, liver, blood, and urine. Cytochrome P450 (CYP) expression was measured in bladder and liver. This dataset provides each PCB and OH-PCB concentration in different tissue types, as well as the quality assurance and quality control (QA/QC) results. CYP expressions in bladder and liver were also reported in the dataset.

Source: Iowa Research Online (The University of Iowa)

DOI: 10.25820/data.008178