Circadian timing of the dystrophin associated complex across the brain and body
Year: 2026
Type: article
Abstract: The dystrophin associated complex (DAC) is an integral membrane scaffold that regulates cellular polarization and structural organization in both brain and peripheral tissues. In the brain, the DAC anchors the water channel aquaporin 4 (AQP4) to astrocytic vascular endfeet, thereby supporting glymphatic waste clearance during the inactive phase. Recent studies have raised the question of whether DAC gene expression is under circadian control. By mining four independent circadian transcriptome and translatome databases, covering multiple brain regions, peripheral tissues, ages, and species, we show that both Aqp4 and the DAC components exhibit circadian rhythms in gene expression across most of the brain and body in mice, chickens and baboons. In addition, Aqp1 shows circadian rhythmicity in peripheral tissues. The phase of these rhythms varies by tissue type yet collectively supports the hypothesis that clock-regulated DAC activity represents a conserved mechanism for coordinating ion, water, and structural homeostasis throughout the body.
Source: Fluids and Barriers of the CNS
Institutions: University of Rochester Medicine, University of Copenhagen
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,390
Funders: Simons Foundation, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, Cure Alzheimer's Fund, Lundbeckfonden, Novo Nordisk Fonden, H. Lundbeck A/S, National Institutes of Health, National Institute of Neurological Disorders and Stroke, National Center for Complementary and Integrative Health
OpenAlex ID: W7128715990