Risk factors for the development of subretinal fluid in the fellow eyes of patients with chronic central serous chorioretinopathy
Year: 2026
Type: article
Study design: Observational Study
Abstract: PURPOSE: To assess the risk of subretinal fluid (SRF) development in the fellow eye of chronic central serous chorioretinopathy (cCSC) patients with unilateral SRF at baseline. METHODS: Medical records of 334 presumed cCSC patients were retrospectively reviewed. Multimodal imaging was evaluated, and the available optical coherence tomography (OCT) scans were screened for SRF development in the fellow eye during follow-up. RESULTS: Of 213 confirmed cCSC cases, 74 (35%) had bilateral SRF at baseline. Among 102 patients with unilateral SRF that met all inclusion criteria, 7/102 (7%) developed SRF in the fellow eye over a mean follow-up of 20.4 months. Retinal pigment epithelial (RPE) alterations in the fellow eye were present at baseline in 7/7 (100%) who developed SRF, compared to 59/95 (62%) in those who did not (p = 0.042). Subfoveal choroidal thickness (SFCT) was higher in the SRF-developing group (482.3 vs. 365.9 μm; p = 0.306), although not significantly. Hyperautofluorescence on fundus autofluorescence (FAF) at baseline occurred in 6/7 (86%) of the SRF-developing group versus 25/91 (28%) who did not (p = 0.004). The ellipsoid zone was interrupted in 5/7 (71%) of SRF-developing patients versus 28/95 (30%) who did not develop SRF (p = 0.005). CONCLUSION: The risk of SRF development in the fellow eye of cCSC patients with unilateral SRF is relatively low over a follow-up period of almost 2 years. No statistically significant risk factors were identified after correction for multiple testing; however, certain trends were observed.
Source: Acta Ophthalmologica
DOI: 10.1111/aos.70103
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,990
Funders: Universiteit Leiden, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Algemene Nederlandse Vereniging ter voorkoming van Blindheid, Landelijke Stichting voor Blinden en Slechtzienden, Stichting Retina Fonds, Stichting voor Ooglijders, Rotterdamse Stichting Blindenbelangen, Stichting Blinden-Penning, Stichting Blindenhulp, Stichting Leids Oogheelkundig Ondersteuningsfonds
OpenAlex ID: W7128721948