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The Total Synthesis of Chlorotricolide: the Top Half

Year: 2026

Type: dissertation

Abstract: The total synthesis of the top half of chlorotricolide 2, is described. The top half 65 was prepared in 14 steps (10% overall yield) from tartaric acid. The potential usefulness of this top half in the total synthesis of chlorotricolide was demonstrated by connection to bottom half models. Successful deprotection of the α-hydroxy-tetronic acid dimethyl ether moiety is also described. See figures in PDF of thesis.

Source: Caltech Library

DOI: 10.7907/m8zt-ek15

Author: Thompson, Wayne Julius

Institution: California Institute of Technology

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: California Institute of Technology

OpenAlex ID: W7128726006

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