Work

Oligodendrocytes Are Active Participants in the Pathogenesis of Multiple Sclerosis and Its Animal Models

Year: 2026

Type: article

Abstract: Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are autoimmune inflammatory demyelinating diseases of the central nervous system (CNS). For decades, oligodendrocytes were regarded as passive targets of autoimmune inflammation in these conditions. However, recent studies challenge this view, revealing that oligodendrocytes are active participants-not just passive targets-in the pathogenesis of MS and EAE. In this review, we summarize recent research that highlights the active and dynamic roles of oligodendrocytes in these diseases.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms27041779

Authors: Min Li Lin, Wensheng Lin

Institution: University of Minnesota

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499