Multi-omics profiling reveals CDKN2A mutant early-onset lung squamous cell carcinoma with a “hot” tumor immune microenvironment
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: Early-onset lung squamous cell carcinoma (LUSC) is a rare and poorly characterized entity. Its distinct clinicopathological, genomic, and tumor immune microenvironment (TIME) profiles remain to be elucidated. This study sought to explore the molecular landscape and immunophenotype of early-onset LUSC, with a focus on uncovering potential genomic associations with its clinical features. Methods: In this retrospective, single-center cohort study, we conducted a comprehensive multi-omics analysis on patients with surgically resected, treatment-naïve early-onset LUSC (subjects aged ≤40 years, n=21) between 2015 and 2024 using whole-exome sequencing (WES) and digital spatial profiling (DSP). To contextualize our findings, we conducted a comparative analysis using publicly available LUSC data from The Cancer Genome Atlas (TCGA) via the Xena platform. Results: group showed a trend toward shorter overall survival (OS). Conclusions: status as a potential biomarker to guide immunotherapy strategies in early-onset LUSC.
Authors: Ying Zhang, Pei Yuan, Bingzhi Wang, Lina Gao, Bingning Wang, Xin Hao, Lei Guo, Jianming Ying
Language: English
Topic: Lung Cancer Research Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7128739940
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