Year: 2026
Type: preprint
Abstract: Introduction: Pregnancy is a critical test of women's cardiovascular risk. Structural factors may influence long-term cardiovascular health beyond individual, social experiences. We examined associations of neighborhood-level deprivation and individual-level social vulnerability (SV) during pregnancy with postpartum blood pressure (BP). Methods: This secondary analysis of a prospective cohort study used data from 3,728 nulliparous women in the nuMoM2b-HHS cohort followed from early pregnancy to 2-7 years post-delivery (Mage: 30.8 years, 65% non-Hispanic White, 14% with adverse pregnancy outcomes [APOs]). Multivariable linear and logistic regression models tested relations of the Area Deprivation Index (ADI) and SV (a composite of perceived stress, discrimination, pregnancy experiences, social support, health literacy, depression, and anxiety) with systolic BP (SBP), diastolic BP (DBP), and incident hypertension, adjusting for demographic and behavioral covariates. Effect modification by APO history was assessed. Results: >0.20). Conclusions: Neighborhood deprivation during pregnancy was associated with higher BP up to seven years later, independent of individual social vulnerability. Structural context during pregnancy may contribute to early maternal cardiovascular risk.
Source: medRxiv
Language: English
Subfield: Health
Field: Social Sciences
Domain: Social Sciences
Open Access status: green
Funders: Cedars-Sinai Medical Center, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Child Health and Human Development, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1874132231, G1985244758, Pregnancy as a Window to Future Cardiovascular Health: Adverse Pregnancy Outcomes, G2528027702, G2739097742, Social Vulnerability, Sleep, and Early Hypertension Risk in Younger Adults, UCLA Clinical and Translational Science Institute, G3687849506, G3979097675, G4206105981, Pregnancy as a Window for Future Cardiovascular Health, G4227382501, G427181341, Pregnancy as a Window to Future Cardiovascular Health, G4581697588, G4816428913, G4851127443, G4853807150, G515473234, G5193801537, G5583988917, Pregnancy as a Window to Future Cardiovascular Health, Pregnancy as a Window to Future Cardiovascular Health, Pregnancy as a Window to Future Cardiovascular Health, G6048534641, G660179165, G7273856610, G7594658276, G801680829, Clinical and Translational Science Collaborative of Cleveland, Institute for Clinical and Translational Science, G9000014608, G9000047893, G9000082444, G9000119374, G9000306557, Continuation of the NuMoM2b Heart Health Study, G980253153
OpenAlex ID: W7128742301