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Loss of cystathionine-β-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome

Year: 2026
Type: article
DOI: 10.1016/j.bcp.2026.117815
Authors: Jenna Thibodeau, Jianlei Zhao, Holly Edwards, Lisa Polin, Juiwanna Kushner, Sijana H Dzinic, Kathryn White, Kian Hershberger, Yongwei Su, Tasnim Arroum, Lucynda Pham, Lauren Pavelich, Raina Awdish, Jacob LaValley, Austin C. Boucher, Wei Chen, Jing Li, Xun Bao, Maik Hüttemann, Jessica B. Back, Joshua E. Allen, Varun V. Prabhu, John D Crispino, Jeffrey W. Taub, Yubin Ge
Institutions: Wayne State University, The Barbara Ann Karmanos Cancer Institute, St. Jude Children's Research Hospital, Chimerix (United States), Central Michigan University, Children's Hospital of Michigan
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: green
Awards: Enhancing treatments for myeloid leukemia associated with Down syndrome, G3125488830, G409676155, The paradox of myeloid leukemia of Down syndrome, G8274784503, Training Program in the Biology of Cancer, CANCER CENTER SUPPORT GRANT
OpenAlex ID: W7128768494
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Cites: 32
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