Work

Severe exfoliative dermatitis induced by apalutamide in a mHSPC patient: A case report

Year: 2026

Type: article

Abstract: RATIONALE: Apalutamide is a generation androgen antagonist for the treatment of metastatic hormone sensitive prostate cancer and non-metastatic castration resistant prostate cancer. Skin adverse reactions caused by apalutamide are mostly rashes and maculopapules. PATIENT CONCERNS: There are a few reports about exfoliative dermatitis caused by apalutamide. DIAGNOSES: Severe exfoliative dermatitis induced by apalutamide. INTERVENTIONS: Gamma globulin, cefoperazone sulbactam sodium, albumin, ebastine, loratadine, hydrocortisone cream, and 3% boric acid lotion. OUTCOMES: Whole-body skin was red, without exudation, and with a small amount of desquamation. LESSONS: The incidence of exfoliative dermatitis due to apalutamide is low but severe, and if a serious adverse skin reaction is suspected, apalutamide needs to be discontinued immediately and treated accordingly.

Source: Medicine

DOI: 10.1097/md.0000000000047428

Authors: Hanzhong Chen, Teng Li, Junhong Fan, Jiumin Liu

Institutions: Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University

Language: English

Topic: Chemotherapy-related skin toxicity

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950