Associations of baseline characteristics, patient-reported outcomes, and satisfaction with pain therapy with the patient's global impression of change: a prospective cohort study
Year: 2026
Type: article
Abstract: BACKGROUND: Patient-reported outcome measures (PROMs) are key elements of assessing the efficacy of perioperative pain management. Here, we aimed to capture the association of 10 individually reported aspects of patient's specific impression of change since surgery (PSIC) related to four outcome domains of a previously defined core outcome set, relative to the patient's global impression of change (PGIC). We further evaluated the influence of type of surgery, sex, preoperative baseline characteristics, and satisfaction with pain management on PGIC. METHODS: This exploratory analysis used the PROMPT NIT-1 study data (2661 patients, 18 sites, four surgery types: total knee arthroplasty, sternotomy, breast cancer surgery, or endometriosis surgery). Male and female adults were included. All PROMs were assessed on postoperative day 3. We used ordinal regression models with PGIC as a dependent variable and PSICs as independent variables. RESULTS: of 0.55 (relative domain contributions: pain intensity 55%, self-efficacy 19%, adverse events 15%, and pain-related interference of physical functioning 10%). Pain-related worrying and depression had no association with the PGIC, whereas anxiety, preoperative pain, opioid intake, low satisfaction with and wish for more treatment, low treatment agency, and overall dissatisfaction were associated with less improvement after surgery. Receiving information about treatment was associated with greater improvement on the PGIC. CONCLUSIONS: Although all four domains contributed to PGIC after surgery, pain intensity was the most important. These findings highlight the importance of both managing postoperative pain and optimising patient experience by addressing self-efficacy, adverse events, and pain-related interference of physical functioning. CLINICAL TRIAL REGISTRATION: NCT03834922.
Source: British Journal of Anaesthesia
Institutions: University of Exeter, Jena University Hospital, Friedrich Schiller University Jena, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Hôpital Ambroise-Paré, Cliniques Universitaires Saint-Luc, UCLouvain, University of Helsinki, Helsinki University Hospital, University Hospital Münster
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,450
Funders: University of Bern, Univerzitet u Beogradu, European Federation of Pharmaceutical Industries and Associations, Inselspital, Universitätsspital Bern, National Institute for Health and Care Research, European Commission, Technische Universität Dresden, Universität des Saarlandes, Hôpitaux Universitaires de Genève, Universitätsklinikum Jena, Università degli Studi della Campania Luigi Vanvitelli, Innovative Medicines Initiative, Instituto Português de Oncologia do Porto, Barts Health NHS Trust, Horizon 2020 Framework Programme, Horizon 2020, NIHR Exeter Clinical Research Facility
OpenAlex ID: W7128773337