Work

A12 Impact of Cadx on Optical Diagnosis of Serrated and Advanced Colorectal Lesions: a Prospective Implementation Study

Year: 2026

Type: article

Abstract: Background Computer Aided Diagnosis (CADx) can classify colorectal polyps as either neoplastic or hyperplastic during colonoscopy. Aims We aimed to assess CADx performance and its impact on endoscopist optical diagnosis for sessile serrated lesions (SSLs), traditional serrated adenomas (TSAs), adenomas with advanced histology, and cancers in an implementation study. Methods We performed a secondary analysis of a large prospective colonoscopy cohort. All patients with SSLs, TSAs, advanced adenomas and/or cancers detected, and prospectively documented CADx-assisted or unassisted optical diagnoses were included. The primary outcome was the sensitivity of CADx-assisted and unassisted optical diagnoses for SSL identification. Secondary outcomes included diagnostic performance metrics for SSL, TSA, advanced adenoma, cancer identification and the impact of CADx output on endoscopists’ optical diagnoses. Results In 2622 patients with 2456 eligible polyps, there were 140(5.7%) SSLs, 22(0.9%) TSAs, 213(8.7%) advanced adenomas, and 13(0.5%) cancers. Sensitivity for SSL identification of CADx-assisted and unassisted optical diagnosis was 55.7% (95%CI 42.9-67.8) and 38.6% (95%CI 22.7-57.3) respectively; p = 0.12 (Table 1). In CADx-assisted cases, endoscopists correctly identified SSLs more frequently when CADx classified these as non-neoplastic (56/79 cases) compared to neoplastic (23/79 cases),(66.7%[95%CI 51.8-78.9] vs 24.5%[95%CI 10.8-46.3]; p < 0.001), Figure 1. Sensitivity for TSA identification as neoplastic by CADx output was 61.6%(8/13), but CADx-assisted and unassisted endoscopist optical diagnosis identified TSAs as neoplastic in 91.1% and 77.8% of cases respectively. Conclusions CADx use did neither harm nor improve optical diagnostic performance in polyps with SSL, TSA, advanced adenoma, or cancerous histology despite CADx inability to adequately classify these lesions, supporting safety but highlighting a key limitation of current CADx systems. Sensitivity for identification of these lesions trended universally higher with CADx-assisted optical diagnosis, though both CADx-assisted and unassisted ability to recognize SSLs, TSAs, and cancerous lesions remained low. Funding Agencies CIHRTRIANGLE

Source: Journal of the Canadian Association of Gastroenterology

DOI: 10.1093/jcag/gwaf042.012

Authors: M Oleksiw, D K Rex, H Pohl, C Hassan, R Djinbachian, D von Renteln

Institutions: Centre Hospitalier de l’Université de Montréal, Indiana University School of Medicine, Dartmouth College, IRCCS Humanitas Research Hospital

Language: English

Topic: Colorectal Cancer Screening and Detection

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,198