Detecting early memory changes in preclinical Alzheimer's disease using TabCAT favorites test: Data from the European Prevention of Alzheimer's Disease (EPAD) cohort
Year: 2026
Type: article
Abstract: INTRODUCTION: Sensitive memory paradigms may allow the detection of subtle memory changes associated with early Alzheimer's pathology in individuals without established clinical symptomatology. METHODS: We explored the cross-sectional association between performance on Tablet-based Cognitive Assessment Tool (TabCAT) Favorites, a brief computerized memory test, with cerebrospinal fluid AT status (A for amyloid-β and T for phosphorylated tau) and its discriminative validity in 727 clinically asymptomatic participants from the European Prevention of Alzheimer's Disease (EPAD) Longitudinal Cohort Study. Episodic memory was also evaluated with the Repeatable Battery for the Assessment of Neuropsychological Status Delayed Memory Index (RBANS-MI). RESULTS: Compared to A-T- individuals, poorer TabCAT Favorites Total Correct (Favorites-TC) cross-sectional performance was associated with an increased likelihood of A+T+ status, but not A+T- status. There were no significant associations between AT status and RBANS-MI. Among individuals with low Favorites-TC performance, AT status predicted progression on the Clinical Dementia Rating > 0. DISCUSSION: Favorites-TC is a sensitive measure for the early detection of cognitive changes in the early stages of the AD continuum. HIGHLIGHTS: We explored Tablet-based Cognitive Assessment Tool (TabCAT) Favorites scores and cerebrospinal fluid (CSF) AT status (A for amyloid-β and T for phosphorylated tau) in asymptomatic individuals. Poorer Favorites performance linked to higher A+T+ likelihood. TabCAT Favorites is a sensitive tool for detecting early cognitive changes in Alzheimer's disease (AD).
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.71035
Institutions: Universitat de Vic - Universitat Central de Catalunya, Pasqual Maragall Foundation, Barcelonaβeta Brain Research Center, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Global Brain Health Institute, Hospital del Mar Research Institute, University of California, San Francisco, Northern California Institute for Research and Education, Vanderbilt University, Vanderbilt University Medical Center, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Centro de Investigación Biomédica en Red
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
Funders: Foundation for the National Institutes of Health, Alzheimer's Association, European Federation of Pharmaceutical Industries and Associations, Ministerio de Ciencia, Innovación y Universidades, Global Brain Health Institute, Ministerio de Ciencia e Innovación, Innovative Medicines Initiative, National Institutes of Health, Instituto de Salud Carlos III, National Institute on Aging, National Institute of Neurological Disorders and Stroke, EIT Digital
Awards: The Role of Pregnancy History in Women at Risk for Alzheimer’s disease, Caracterización del sueño con medidas de actigrafía y orexina en LCR y su asociación con biomarcadores en enfermedad de Alzheimer preclínica, G2293762934, G2420205988, G2796862820, G2956488051, Social determinants of racial and ethnic disparities in ADRD diagnostic pathways, G3382939337, G346597413, G5349571231, G546892100, G5805502524, G602074769, G6211468113, G6731524417, European Prevention of Alzheimer's Dementia Consortium Data & Sample Access, Optimization of Blood Biomarker Use in AD Clinical Trials, G8181105605, G9000060917, G9000144925, Bridging Research Infrastructure for Dementia Gaps in East Africa (BRIDGE-AFRICA), The spectrum of cognitive impairment including Alzheimer’s Disease and Related Dementias after liver transplantation
OpenAlex ID: W7128784380