Correction: Promiscuous class II-binding SARS-CoV-2-nuc derived vaccine-peptide induced extensive conventional, innate and unconventional T cell responses
Year: 2026
Type: erratum
Abstract: Adding/removing text The vaccine peptide was incorrectly described as a 16-mer; it should be referred to as a 15-mer. A correction has been made to the section Discussion: "This study reveals a multi-layered immune response elicited by a single 15-mer aliphatic peptide in two individuals" The original version of this article has been updated.The peptide sequence and length were incorrectly stated as the 16-mer LLLLDRLLNQLESKMS throughout the manuscript. This has been corrected to the accurate 15-mer vaccine peptide sequence, LLLLDRLNQLESKMS, in all relevant instances. The original version of this article has been updated.Marked in blue: Incorrect citations in which an entirely wrong article was referenced are highlighted in blue.Marked in green: Citations that originally referred to the correct article but now have become incorrect in the corrected article due to changes in the numbering and ordering of the reference list are highlighted in green. These citations must be updated in the respective text passages to reflect their new numbering. An updated reference list is provided at the end of this document.The reference for "For the same TCRs, it is shown that the germline-encoded parts of the CDR3 region of the TCRα chain do not contact the target peptide, but only one or a few N-nucleotide encoded amino acids which, very importantly, are identical or charge-conserved in TCRs of the same specificity. Successive studies showed the same result" was erroneously written as 46. Gabernet The reference for "Strikingly, the CDR3 sequences of the overlap repertoire and the most common vaccine-reactive ab T clonotypes (Table 5) lack or have only few N nucleotides, assigning them to the neonatal TCRs derived from TDT-negative precursors, which persist throughout life, are highly shared between individuals and are reported to be disease-associated The reference for "The vast majority of Vd2-clonotypes in this study was private (Supplementary Table 3) with unique V(D)J rearrangements, individual CDR3-length and no relatedness to each other or to clones from the other donor, resembling Vd1 and adaptive ab-T cells, which undergo profound and highly focused clonal expansions from an originally diverse and private TCR-repertoire in response to specific immune challenges" was erroneously written as "In this context another report is significant (83) Vδ1+-γδ-T cells derived in vitro from human hematopoietic stem and progenitor cell (HSPC) can react with and expand in response to HLA-A2presented melanoma antigen MART-1. The binding of the respective γδ-TCRs to MART-1-pMHC is less peptide-centric as compared to the interaction with a MART-1-specific αβ-TCR and it is speculated that MART-1 may act as specific stabilizer for the MHC for proper recognition by the respective γδ-TCRs. Intriguingly, the heteroclite peptide MART-1- (26)(27)(28)(29)(30)(31)(32)(33)(34)(35) ELAGIGILTV is highly aliphatic: 8/10 amino acids are hydrophobic (83)." The original version of this article has been updated.There was a mistake in Table 1 as published. The peptide sequence and length were incorrectly stated as the 16-mer LLLLDRLLNQLESKMS. This has been corrected to the accurate 15-mer vaccine peptide sequence, LLLLDRLNQLESKMS. The corrected Table 1 appears below.AA position in SARS-Cov-2 nuc Peptide length LLLLDRLNQLESKMS Pept.Pos: 1 -4 -7 (40) The original version of this article has been updated.There was a mistake in the caption of There was a mistake in the caption of Table 3 as published. The color of aliphatic (hydrophobic) amino acids was incorrectly labeled as red, the color of basic amino acids was incorrectly labeled as green. The corrected caption of Abbreviations in CDR3 sequence column: "ident." for identical sequences, "con." for convergent sequences. Convergent sequences show the same nucleotide sequence but are derived from rearrangements involving different VDJ segments. Screening for the public nature of a clonotype was performed using the iReceptor Scientific Gateway of the iReceptor platform (60).The original version of this article has been updated.There was a mistake in the caption of Table 5 as published. The color of aliphatic (hydrophobic) amino acids was incorrectly labeled as red and bold, the color of basic amino acids was incorrectly labeled as green and bold. Additionally, the reference for the citation "iReceptor Scientific Gateway of the iReceptor platform" was erroneously written as N-Nucleotide encoded amino acids are underlined and bold, alphatic amino acids are green and bold, basic amino acids are red and bold. Screening for the public nature of a clonotype was performed using the iReceptor Scientific Gateway of the iReceptor platform (60).The original version of this article has been updated.There was a mistake in the caption of Table 8 as published. The color of aliphatic (hydrophobic) amino acids was incorrectly labeled as red, the color of basic amino acids was incorrectly labeled as green. The corrected caption of Table 8 appears below."Aliphatic amino acids are marked in green, basic amino acids in red. CDR3 regions are given in bold."The original version of this article has been updated.
Source: Frontiers in Immunology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7128790622
Cites:
Cited by:
Related to: