Year: 2026
Type: article
Study design: Systematic Review
Abstract: NNT color recommendation Black (Harms > Benefits) Summary heading Higher MAP targets are likely associated with increased 28-day allcause mortality, less RRT-free days, and increased risk of arrhythmia Benefits in NNT No one was helped (28-day all-cause mortality, 90-day all-cause mortality, RRT requirement, RRT-free days, and risk of arrhythmia) Benefits in percentages (absolute risk reduction) No one was helped Harms in NNT (NNH) 1 in 29 were harmed (increased 28-day all-cause mortality) 1 in 68 were harmed (increased risk of arrhythmia) No one was harmed (RRT requirement) 1.64 days decrease in RRT-free days No one was harmed (90-day all-cause mortality) Harms in percentages 3.4% higher risk of 28-day all-cause mortality with higher MAP targets 1.5% higher risk of arrhythmia with higher MAP targets No change in RRT requirement 1.64 days decrease in RRT-free days No change in 90-day all-cause mortality Efficacy endpoints 28-day all-cause mortality, 90-day all-cause mortality, RRT-free days, RRT requirements Harm endpoints 28-day all-cause mortality, 90-day all-cause mortality, RRTfree days, RRT-requirement, and adverse reactions Who was in the studies Four randomized trials with 3873 participants ≥ 18 years of age with vasodilatory shock requiring vasopressor support Abbreviations: MAP-mean arterial pressure; RRT-renal replacement therapy.
Source: Academic Emergency Medicine
DOI: 10.1111/acem.70240
Authors: Brit Long, Michael Gottlieb
Institutions: University of Virginia, Rush University Medical Center
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,900
OpenAlex ID: W7128798007