Work

Research Progress on Construction Technology of 3D Human Skin Models and Its Application Prospects in Dermatology

Year: 2026

Type: article

Abstract: Traditional two-dimensional (2D) cell cultures and animal models often fail to replicate the complex layered structure and pathological microenvironment of human skin. This paper systematically reviews the latest advancements in three-dimensional (3D) human skin model construction, specifically focusing on bioprinting, organoid, and organ-on-a-chip technologies. Our analysis highlights that the integration of vascularization, skin appendages, and multi-omics data represents the core advancements in enhancing physiological realism for simulating. Despite these strides, challenges such as a lack of standardization and high medical costs remain as barriers to clinical translation. We conclude that future directions must leverage interdisciplinary synergy-integrating artificial intelligence and personalized multi-omics-will be essential to transition 3D skin models from laboratory tools to precise clinical applications.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms27041808

Authors: Liping Li, Wenqi Si, Zhehu Jin, Wenyu Jin

Institutions: Yanbian University, Yanbian University Hospital

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499