Year: 2026
Type: article
Abstract: Pulmonary hypertension is a disease of the lung vasculature, which eventually leads to heart dysfunction. Despite the advances in the discovery and development of new treatments, most of them are aimed to palliate symptoms. Thus, it is crucial to identify novel potential targets directly acting on vascular remodeling. Further understanding of this pathological event is needed to completely describe the disease's mechanisms and effectively generate therapeutical strategies able to cure the disease. Here, we propose an integrative perspective of studying pulmonary hypertension based on the interactions between the vascular cells and their surroundings. This review describes the crosstalk between vascular cells and immune cells in the diseased vasculature, highlighting the central role of this axis and the importance of healthy cell-to-cell communication. Furthermore, we discuss the possibility of considering the pulmonary microenvironment as a key pathological factor in pulmonary hypertension.
Source: Comprehensive physiology
DOI: 10.1002/cph4.70110
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: Fundació la Marató de TV3, Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades, Ministerio de Ciencia e Innovación, Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Fundación Contra la Hipertensión Pulmonar, Consejo Superior de Investigaciones Científicas, European Regional Development Fund, Agencia Estatal de Investigación
Awards: G1105844351, G1175115578, G1211500056, G121809054, G1247757166, G1349575567, G1855990336, G2262748287, G2309174360, G2660406951, G279363373, G300979063, G34346518, G3480869486, G3802802504, G4006201624, G410571670, G425668148, G430777504, G451917667, G488842982, G491712853, G4936363825, G5080475149, G5341597027, G5421974903, G5480866749, G5528311355, G5539308778, G5961725498, G5967599077, G7084143925, G7805626310, G7863371703, G7919402603, G8434830731, G8497050386, G901822112, G929308097, G99296377
OpenAlex ID: W7128805850