Work

Long‐term neurological and psychiatric outcomes after paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis

Year: 2026

Type: article

Abstract: AIM: To examine long-term outcomes in children and adolescents after first-time arterial ischaemic stroke (AIS) or cerebral sinovenous thrombosis (CSVT). METHOD: Patients (0-18 years) diagnosed with a first-time cerebral thrombosis between 1994 and 2006 were followed until 2017 in this descriptive follow-up study. Patients were identified, and age- and sex-matched 1:10 with individuals from the general population. Data were extracted from national registries of patients. Outcomes included all-cause mortality, and hospital diagnoses of neurological and psychiatric disorders after cerebral thrombosis. RESULTS: A total of 251 patients with cerebral thrombosis were followed up for a median of 16 years (interquartile range 13 years 1 month-19 years 4 months). Cumulative all-cause mortality at 23 years 8 months was 11.4% (95% confidence interval [CI] 7.1-17.9). Hazard ratios indicated an increased risk of 64.0 times (95% CI 35.3-116.0) for cerebral palsy, 17.9 times (95% CI 10.2-31.5) for vision problems, and 4.1 times (95% CI 2.0-8.4) for being diagnosed with severe mental disorders during follow-up for those with previous cerebral thrombosis compared with the general population. The risk of morbidity was significantly increased following both AIS and CSVT. INTERPRETATION: Children and adolescents experience a higher all-cause mortality and a high risk of neurological and psychiatric diagnoses after AIS or CSVT compared with the general population.

Source: Developmental Medicine & Child Neurology

DOI: 10.1111/dmcn.70202

Authors: Jeanette Soenderlyng Springer, Søren Paaske Johnsen, Charlotte Olesen, Jan Brink Valentin, Ruta Tuckuviene