Diagnosis and treatment of gallbladder and gastric multiple primary malignancies
Year: 2026
Type: article
Study design: Case Report
Abstract: Plain Language Summary Multiple primary malignancies are rare and challenging to diagnose when they occur simultaneously. Treatment differs from that of single cancer. A case report describes a patient initially diagnosed with metastatic gallbladder cancer from gastric cancer, but postoperative tests showed concurrent malignancies in both organs. The patient received 3 cycles of SOX neoadjuvant chemotherapy, followed by laparoscopic radical cholecystectomy with liver wedge resection and D2 total gastrectomy with Roux-en-Y reconstruction. Postoperatively, the patient underwent adjuvant SOX chemotherapy, but liver metastasis occurred at 6 months, peritoneal dissemination at 9 months, and she unfortunately died at 11 months after surgery. Interestingly, the patient's gallbladder tumor responded well to SOX chemotherapy, usually used for gastric cancer, despite gallbladder cancer's typical resistance to such treatment. This suggests a need for careful diagnostic methods and personalized treatment approaches. The case also indicates that the SOX regimen might be a new treatment option for gallbladder cancer. Plain Language SummaryA rare case of a patient with simultaneous gallbladder and gastric cancers highlights the complexity of diagnosing and treating multiple primary malignancies. Initially thought to be metastatic gallbladder cancer, further tests revealed separate cancers in both organs. The patient underwent SOX chemotherapy, surgery, and additional chemotherapy, but unfortunately died 11 months post-surgery due to liver and peritoneal metastases. Notably, the gallbladder tumor responded well to SOX chemotherapy, typically used for gastric cancer, suggesting potential for this regimen in treating gallbladder cancer. This case underscores the importance of precise diagnosis and personalized treatment strategies for complex cancer cases. Text is machine generated and may contain inaccuracies. FAQ
Source: Journal of Pancreatology
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7128807643