Work

Pseudomonas Aeruginosa Biophil Formation Mechanisms and Antibiotic Resistance Relating to Current Issues

Year: 2026

Type: conference-paper

Abstract: Pseudomonas aeruginosa is an opportunistic pathogen that forms biofilms and is highly resistant to antibiotics. This study investigated the steps of bifilm formation, the mechanism of quorum sensing, and the antibiogram profile using a novel approach. Crystal violet assay and MIC detection methods were used to determine the 72-hour biofilm density (OD 0.912) and 10–128-fold resistance to antibiotics. Furanone-AHL quorum sensing inhibitor was shown to have an 80% biofilm reduction effect. The results provide a basis for a biofilm-fighting strategy as a promising solution for QS-opponent therapy.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18635505

Authors: Buriyev Muhammadali Gayrat oglu, Akhmedov Ulugbek Xolbek oglu, Khushboqov Shohruh Ulug'bek oglu

Institution: Termez University of Economics and Service

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7128810469

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