Extracellular Particles Derived From Mesenchymal Stromal Cells Reduce Pseudomonas aeruginosa Lung Infection and Inflammation in Mice

Year: 2026

Type: article

Abstract: ABSTRACT The World Health Organization and the U.S. Centre for Disease Control and Prevention have reported that antibiotic‐resistant infections with Pseudomonas aeruginosa present a significant health risk worldwide. In the genetic disease Cystic Fibrosis (CF), chronic antibiotic‐resistant Pseudomonas lung infections and persistent inflammation remain the leading causes of mortality. While highly effective modulator therapy (HEMT) dramatically improves lung function in CF, they fail to eradicate chronic infections or eliminate the associated hyperinflammatory state. Thus, there is an urgent need for innovative therapies that can simultaneously eliminate antibiotic‐resistant P. aeruginosa lung infection and the attendant hyperinflammatory lung environment. Mesenchymal stromal cell‐derived extracellular particles (MSC EPs) represent a promising solution, offering potent anti‐inflammatory and antimicrobial properties while being safe and non‐toxic. This study demonstrates, using a CF mouse model of infection, that MSC EPs reduce acute P. aeruginosa lung infection and inflammation. As the first investigation of MSC EPs in CF mice, this research underscores the dual effects of MSC EPs; reducing inflammation and bacterial burden. These findings mark an important advancement in antimicrobial therapy, addressing the unmet need for reducing antibiotic‐resistant infections and hyperinflammation in CF as well as other diseases with chronic, antibiotic‐resistant P. aeruginosa infections.

Source: Journal of Extracellular Biology

DOI: 10.1002/jex2.70114

Authors: Sharanya Sarkar, Roxanna Barnaby, Zachary Faber, Lily Taub, Carolyn Roche, Lily A. Charpentier, Thomas H. Hampton, Brad Vietje, Douglas J. Taatjes, Byoung‐Kyu Cho, Young Ah Goo, Matthew J. Wargo, Daniel J. Weiss, Tracey L. Bonfield, Thomas J. Kelley, Bruce A. Stanton

Institutions: Dartmouth College, Case Western Reserve University, University of Vermont, Washington University in St. Louis, Genome Technology Access Center

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,260

Funders: Cystic Fibrosis Foundation, Institute of Clinical and Translational Sciences, Dartmouth College, Alvin J. Siteman Cancer Center, Georgia Clinical and Translational Science Alliance, Dartmouth Cancer Center, Bundesinstitut für Bau- Stadt- und Raumforschung, National Institutes of Health, National Cancer Institute, National Center for Advancing Translational Sciences

OpenAlex ID: W7128810913