Work

Effective Management of Late Inflammatory Nodules Following Hyaluronic Acid Fillers: A Case Series Treated With Methotrexate

Year: 2026

Type: article

Abstract: With the rising popularity of hyaluronic acid (HA) fillers for cosmetic purposes, complications such as delayed-onset edema and nodules have become more frequent. These adverse reactions may be challenging to treat and often require multiple therapeutic strategies. We report 3 cases of women who developed late-onset edema and firm nodules following HA filler procedures. Conventional treatments, including corticosteroids, antibiotics, and hyaluronidase, were insufficient. Oral methotrexate at 15 mg per week was introduced, resulting in complete resolution in all cases within approximately 30 days. Low-dose methotrexate proved to be effective in managing persistent nodules and edema secondary to HA fillers. Methotrexate may represent a promising treatment option for delayed inflammatory responses following HA filler injections. Further prospective studies are needed to validate its safety and efficacy in this context.

Source: Plastic & Reconstructive Surgery Global Open

DOI: 10.1097/gox.0000000000007314

Authors: Lígia Piccinini Colucii, Juliana Botelho Carvalho, Isadora Raisa Pimenta Magalhães, Letícia Oba Galvão

Institution: Universidade José do Rosário Vellano

Language: English

Topic: Facial Rejuvenation and Surgery Techniques

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,195