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Diabetes and Pancreatic Cystic Neoplasms—Dangerous Liaisons

Year: 2026

Type: article

Abstract: Cho et al 1 offer an important perspective on whether diabetes is associated with an increased risk of pancreatic cystic neoplasms (PCNs).Using a cohort of more than 3.8 million Korean adults followed up for more than 10 years, the authors report a stepwise increase in PCN incidence across worsening glycemic categories, with the highest risk observed in individuals with diabetes of 5 or more years of duration.The risk increases in younger individuals, men, and current smokers.These findings contribute meaningfully to the evolving understanding of metabolic influences in pancreatic disease.Yet, for clinicians interpreting these data in clinical practice, several methodologic and diagnostic limitations require careful contextualization.

Source: JAMA Network Open

DOI: 10.1001/jamanetworkopen.2025.56869

Authors: Stefano Crippa, Lorenzo Piemonti

Institutions: Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000