Work

Molecular Perspectives on the Association of Air Pollution Biomarkers with Type 2 Diabetes Mellitus and Gestational Diabetes

Year: 2026

Type: article

Abstract: Air pollution is increasingly recognized as a contributor to metabolic disorders, including type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM). The current review analyzes molecular mechanisms linking air pollution exposure to diabetes development, emphasizing the role of oxidative stress, and focusing on well-known biomarkers such as protein modifications, lipid peroxidation, DNA damage, and altered antioxidant capacity. Pollutants such as particulate matter (PM) and ozone induce oxidative stress and inflammation, disrupting insulin signaling and glucose homeostasis. Thus understanding these molecular pathways enhances our ability to identify at-risk populations and develop targeted interventions. This insight bridges environmental exposure and metabolic disease, underscoring urgent public health implications.

Source: Applied Sciences

DOI: 10.3390/app16041898

Authors: Aikaterini Itziou, Vasiliki Michou, Evangelia Lakioti, Vayos Karayannis

Institutions: University of Western Macedonia, Aristotle University of Thessaloniki, University of Thessaly

Language: English

Topic: Air Quality and Health Impacts

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,896