Work

Drimane Sesquiterpenes Isolated from the Fruiting Body of the Clavarioid Fungus Ramaria botrytoides

Year: 2026

Type: article

Abstract: Four previously undescribed drimane-type sesquiterpenoids, ramaribotrytols A–D (1–4), were isolated from the fruiting bodies of the clavarioid fungus Ramaria botrytoides. Their structures and absolute configurations were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses, high-resolution electrospray ionization mass spectrometry (HRESIMS), and electronic circular dichroism (ECD) calculations. Compounds 1–4 are characterized by oxygenation at C-2, a structural feature that is rare within the drimane sesquiterpene family. These findings expand the chemical diversity of secondary metabolites from the medicinal and edible fungus Ramaria and enrich the structural repertoire of drimane-type sesquiterpenoids derived from higher fungi.

Source: Molecules

DOI: 10.3390/molecules31040645

Authors: Gao-Ke Peng, Facheng Su, Ji-Kai Liu, He-Ping Chen, Xinyang Li

Institutions: South Central Minzu University, Kunming Institute of Botany, University of Chinese Academy of Sciences

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funders: National Natural Science Foundation of China, Chinese Academy of Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Institute of Botany, Chinese Academy of Sciences