Work

Minor trauma-induced eccrine porocarcinoma of the toe in a patient on long-term carbamazepine: a case report and literature review

Year: 2026

Type: article

Abstract: Background: Eccrine Porocarcinoma is a rare malignant neoplasm of eccrine sweat gland origin. Its diverse clinical presentation often leads to misdiagnosis and delayed treatment. The potential role of systemic factors, such as long-term medication use, in its pathogenesis is poorly understood. Case presentation: We report a case of a 51-year-old male with a 30-year history of epilepsy on long-term carbamazepine therapy, who developed a refractory ulcerative mass on the left second toe after minor trauma. Toe amputation was performed, and histopathology confirmed Eccrine Porocarcinoma. Conclusions: This case highlights the importance of considering rare malignancies like Eccrine Porocarcinoma in the differential diagnosis of non-healing acral ulcers. An early biopsy is crucial. The long-term use of carbamazepine in this context is noted, and its potential role as a co-factor in tumor development, possibly interacting with local chronic inflammation, is discussed. Further investigation into the influence of systemic medications on the pathogenesis of such rare tumors is warranted.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2026.1727762