Work

Comparative Clinical Evaluation of Platelet-Rich Fibrin with and Without Bioactive Glass Graft (PerioGlas) In Managing Mandibular Grade II Furcation Defects

Year: 2026

Type: article

Abstract: Introduction: Furcation involvement, being one of the most common complications of periodontal disease, is managed by a variety of materials, including autografts, allografts, xenografts, and barrier membranes. The bioactive glass ceramic bone graft PerioGlas exhibits both osteoconductive and biointeractive qualities, and platelet-rich fibrin (PRF) may facilitate the healing of both soft and hard tissues. Objective: The purpose of this clinical study was to compare the results of PRF alone and PRF with PerioGlas in mandibular Grade II furcation defects. Methods: Ten patients with bilateral mandibular molar furcations participated in a split-mouth study, which evaluated radiographic and clinical parameters at baseline, three months, and six months. Results: At six months, both groups had significantly improved, with PRF + PerioGlas producing more bone fill and a smaller defect. Conclusion: PRF works well on a standalone basis, but when combined with PerioGlas, it offers better regenerative results in Grade II furcation defects.

Source: Journal of Pharmacy And Bioallied Sciences

DOI: 10.4103/jpbs.jpbs_1729_25

Authors: Manimekalai, Abhijit Datta, Shanvi Ray, Monica Sinha, Mariea Francis, Radhika P. M. Sooranagi

Institutions: Chettinad Academy of Research and Education, Mithila Minority Dental College And Hospital, KVG Dental College & Hospital

Language: English

Topic: Periodontal Regeneration and Treatments

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $250