Work

Nanobiomaterial-enabled boron delivery systems and innovative strategies for revolutionizing BNCT

Year: 2026

Type: article

Abstract: Boron neutron capture therapy (BNCT) is a novel and emerging form of radiotherapy that combines the advantages of "heavy ion radiotherapy" and "biological targeting". The therapeutic potential of BNCT is ultimately constrained by precise and efficient delivery of boron drugs. In this review, we systematically trace from conventional boron drugs to sophisticated nano-delivery platforms, emphasizing breakthroughs in carrier engineering, targeted delivery strategies, and multifunctional synergistic systems. A dedicated analysis of the biological foundations, such as cell cycle dynamics, tumor microenvironmental interactions, and immunostimulatory effects, provides a crucial framework for understanding mechanism-informed biomaterial design. By synthesizing current advances with an outlook on future challenges, this work aims to chart a course for translating innovative boron-loaded biomaterials from the laboratory into clinical reality, thereby unlocking the full promise of BNCT.

Source: Theranostics

DOI: 10.7150/thno.126209

Authors: Qiyao Yang, Ruxuan Wang, Huang Lingling, Qiong Bian, Qichun Wei

Institutions: Second Affiliated Hospital of Zhejiang University, Zhejiang University, Sir Run Run Shaw Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College

Language: English

Topic: Boron Compounds in Chemistry

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671