Work

Inflammatory phenotype drives different immunosuppressive response in COPD exacerbations

Year: 2026

Type: article

Abstract: BACKGROUND: COPD is heterogeneous, with immunosuppression contributing to immune dysfunction. We hypothesized that the immunosuppressive response varies by inflammatory phenotype during both stable disease (SCOPD) and acute exacerbations (AECOPD). METHODS: COPD patients were monitored during AECOPD hospitalization and subsequent clinical stability. Serum key pro- and anti-inflammatory molecules were measured. Circulating Th17 and regulatory T (Treg) cells, early-myeloid-derived suppressor cells (e-MDSC), monocytic-MDSC (M-MDSC), and plasmacytoid dendritic cells (pDCs) were analyzed by flow cytometry. Sputum was tested for viruses and bacteria. Eosinophilic inflammation was defined by a blood eosinophil count of ≥ 2%. RESULTS: The study included 78 COPD patients and 17 controls. 49% of patients consistently had a non-eosinophilic (Non-Eos) phenotype, and 18% an eosinophilic (Eos) phenotype across both AECOPD and SCOPD. Interestingly, 28% of patients exhibited Non-Eos-AECOPD followed by eosinophilia in SCOPD, while 5% showed the opposite. Immunosuppressive cell frequency increased in both Eos-AECOPD and Non-Eos-AECOPD. While Tregs increases were comparable, the M-MDSC increase in Non-Eos-AECOPD was 1.6 times greater than in Eos-AECOPD. During the stable phase, the Eos phenotype associated with more Tregs and fewer M-MDSCs. Cytokine levels rose significantly during Non-Eos-AECOPD but not in Eos-AECOPD. Critically, within the Non-Eos-AECOPD group, those who later developed eosinophilia in SCOPD showed the most pronounced increases in M-MDSC frequency and cytokine levels. CONCLUSIONS: Immunosuppressive cell distribution in SCOPD and triggered immunosuppression pathways during AECOPD are dependent on the inflammatory profile. Understanding the COPD inflammatory phenotype might help predict immune responses and lead to more targeted treatments. TRIAL REGISTRATION: Not applicable.

Source: BMC Pulmonary Medicine

DOI: 10.1186/s12890-025-04020-1

Authors: Cristina Miralles, María Dolores Miñana, María Luisa Nieto, María del Carmen Aguar, Victoria Domínguez-Márquez, Juan José Soler-Cataluña

Institutions: Hospital Arnau de Vilanova, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Universitat de València

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090