Work

Matching-adjusted indirect comparison analysis of omalizumab versus dupilumab in patients with chronic spontaneous urticaria

Year: 2026

Type: article

Abstract: Background: Omalizumab is a well-established treatment for patients with chronic spontaneous urticaria, and dupilumab is a newly approved treatment. However, the lack of head-to-head randomized trials makes it challenging to compare treatment outcomes between omalizumab and dupilumab. Objective: To overcome this limitation, we used matching-adjusted indirect comparison to assess the efficacy of omalizumab versus dupilumab in primary phase 3 trials. Methods: test. ClinicalTrials.gov identifiers: NCT01287117, 01292473, 04180488. Results: = .031). Change from baseline in UAS7 at week 12 for omalizumab versus placebo was -12.6 (-15.7, -9.5) and for dupilumab versus placebo was -5.0 (-9.3, -0.7). Change from baseline in ISS7 at week 12 for omalizumab versus placebo was -5.4 (-6.9, -4.0) and for dupilumab versus placebo was -2.4 (-4.6, -0.1). Conclusions: Despite limitations, our matching-adjusted indirect comparison analysis highlights that omalizumab is an effective treatment option for appropriate patients with chronic spontaneous urticaria.

Source: Journal of Allergy and Clinical Immunology Global

DOI: 10.1016/j.jacig.2026.100668

Authors: Giselle Mosnaim, Arpamas Seetasith, Michael Holden, Benjamin L. Trzaskoma, Sarbjit S. Saini

Institutions: Endeavor Health, Genentech, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Urticaria and Related Conditions

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000