Work

Distinct mutational signature and clonal evolution in constitutional mismatch repair deficiency-associated high-grade gliomas

Year: 2026

Type: article

Abstract: events and survival of founding clone during tumor recurrence. These findings provide valuable insights into the genomic landscape and clinical outcomes of CMMRD-associated HGGs, emphasizing the critical role of mutational signature and tumor evolution in tumorigenesis and patient prognosis.

Source: iScience

DOI: 10.1016/j.isci.2026.115029

Authors: Chang Li, E. Zeynep Erson-Omay, Yavuz Koksal, Ekrem Unal, Buket Kara, Kaya Bilguvar, Yahya Paksoy, Nimetullah Alper Durmus, Ali Kurtsoy, Huseyin Per, John Rosendahl Østergaard, Murat Günel, Ahmet Okay Çağlayan

Institutions: Yale University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Selçuk University, Hasan Kalyoncu University, Acıbadem University, Erciyes University, Aarhus University Hospital, Dokuz Eylül University, Izmir Biomedicine and Genome Center

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funder: Basic and Applied Basic Research Foundation of Guangdong Province

Award: G6013114507

OpenAlex ID: W7128914107

FWCI:

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