Work

Protective effect of Zymosan-A against radiation-induced premature ovarian insufficiency in a murine model

Year: 2026

Type: article

Abstract: Co γ-radiation-induced murine POI model and evaluated Zymosan-A's efficacy. Results showed Zymosan-A mitigated granulosa cell apoptosis, improved ovarian hormone levels and estrous cycle regularity, increased embryo number, and enhanced offspring weight. Its radioprotective effect against ovarian injury, mediated via the TLRs-NF-κB pathway, was abolished in TLR2-knockout mice. Thus, Zymosan-A effectively protects against radiotherapy-induced POI primarily through the TLR2-NF-κB pathway.

Source: iScience

DOI: 10.1016/j.isci.2026.115027