Aggregation‐Induced Emission in Fertility Preservation of Female Cancer Patients: From Precision Diagnosis and Therapy to Functional Restoration
Year: 2026
Type: article
Abstract: The rising incidence of cancer among young women, coupled with improved survival rates, has significantly increased the demand for effective fertility preservation strategies. It is reported that women diagnosed and treated for cancer have ≈38% lower chances of pregnancy compared to the general population. Current oncology treatments, including surgery, radiotherapy, and chemotherapy, often result in irreversible damage to the ovaries, uterus, and fallopian tubes, highlighting a critical need for innovative approaches to functional restoration. Aggregation‐induced emission (AIE) offers a promising solution to these challenges. AIE possesses unique properties such as high brightness (e.g., AIE achieves tumor‐to‐background ratios up to 15.2), superior photostability, and the ability to generate reactive oxygen species or heat upon light irradiation. This review systematically recent advancements in AIE technology for fertility preservation in female cancer patients. We focus on its applications in early tumor diagnosis and screening, precise surgical navigation, innovative treatment strategies, and the functional assessment and monitoring of reproductive organs. By integrating diagnostics and therapy, we propose that this AIE‐based approach will provide novel strategies for clinical fertility preservation, ultimately shifting the paradigm from mere survival to fertility restoration, thereby significantly enhancing patients’ quality of life.
Source: Small Structures
Authors: Yaoqin Mu, Yanbo Li, Jun Dai, Kezhen Li
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $4,110
Awards: G138420498, G5239621343
OpenAlex ID: W7128916509