USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination
Year: 2026
Type: article
Abstract: with low toxicity. Mechanistically, USP20 interacts with CTNNB1 and stabilizes the CTNNB1 protein via deubiquitination. Cut&tag analysis indicated that USP20 co-localizes with CTNNB1 on the genome, where they jointly regulate target genes in AML. Collectively, our study identified USP20 as a super-enhancer-regulated oncogene maintaining AML cell survival and proliferation through CTNNB1 stabilization. Pharmacologic targeting of USP20 with AS1517499 presents a promising therapeutic strategy targeting the SE-USP20- CTNNB1 axis.
DOI: 10.7150/ijbs.122898
Authors: Jia Cheng, Fang Fang, Zhiheng Li, Jianwei Wang, Linbo Cai, Ling Xu, Yanfang Tao, Juanjuan Yu, Gen Li, Zimu Zhang, Zexi Cui, Yang Yang, Tiandan Li, Di Wu, Xiaolu Li, Yifang Ding, Zong Zhai, Mengmeng Gu, Xue Li, Xingxing Wu, Pengju Yang, Chunxia Shi, Huike Bai, Xiaodong Wang, Lanlan Han, Lei Shi, Jianqin Li, Jian Pan
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W7128919949