Work

Integrative analysis of the PSMA family identifies PSMA6 as an adverse prognostic biomarker promoting bladder cancer cell proliferation

Year: 2026

Type: article

Abstract: Background: Proteasome subunit alpha members (PSMAs) are reported to be involved in diverse biological processes, and mounting evidence indicates that PSMAs have been implicated in the carcinogenesis of various malignancies. Nevertheless, there is a scarcity of reports on the expression, prognostic significance, and potential functions of the PSMA family in bladder cancer (BLCA). Methods: experiments. Results: . Conclusions: Our findings suggested that PSMA6 might function as an unfavorable prognostic biomarker, fostering BLCA cell proliferation, while also potentially serving as a predictive indicator for the efficacy of immunotherapy in BLCA patients.

Source: International Journal of Medical Sciences

DOI: 10.7150/ijms.119034

Authors: Zhengnan Huang, Xiangqian Cao, Yilin Yan, Huaxing Li, Bing Shen, Tengjiao Wang