Molecular Mechanisms of Apoptosis and Its Role in Human Diseases
Year: 2026
Type: article
Abstract: Apoptosis, or programmed cell death, is a highly regulated biological process essential for normal development, tissue homeostasis, and immune regulation. Dysregulation of apoptosis contributes to a wide range of human diseases, including cancer, neurodegenerative disorders, autoimmune conditions, and cardiovascular diseases. Apoptosis occurs through intrinsic (mitochondrial) and extrinsic (death receptor-mediated) pathways, involving caspases and regulatory proteins such as Bcl-2 family members and p53. Understanding the molecular basis of apoptosis provides insight into disease pathogenesis and therapeutic targets. This article reviews the molecular mechanisms of apoptosis, its physiological significance, and its involvement in major human diseases.
Authors: Ro'ziyeva, Gulsara, Turdiqulova, Shoxista
Institution: Termez University of Economics and Service
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7128921672
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