Work

Induction chemotherapy followed by arsenic and all-trans retinoic acid for acute promyelocytic leukemia: Outcomes from a single-center protocol in Singapore

Year: 2026

Type: article

Abstract: KKH-APML 17 is a single-center protocol for the treatment of pediatric acute promyelocytic leukemia (APML) in Singapore, which commences with standard induction chemotherapy followed by arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for consolidation. It was designed to reduce anthracycline exposure while maintaining therapeutic efficacy. All three patients treated with this protocol achieved and maintained morphological and molecular remission. Pseudotumor cerebri was an adverse effect of ATRA treatment but no other major adverse effects were observed. In resource-limited settings where ATO is not readily available, this protocol may serve as an interim measure while awaiting the import of ATO.

Source: Pediatric Hematology Oncology Journal

DOI: 10.1016/j.phoj.2026.100808

Authors: Debbra Jayne Yi Xin Chong, Xue Na Goh, Prasad Iyer

Institutions: KK Women's and Children's Hospital, Duke-NUS Medical School

Language: English

Topic: Retinoids in leukemia and cellular processes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600