Work

A simple, ligand-free Cu(OH)2-catalyzed methoxylation of aryl halides

Year: 2026

Type: article

Abstract: OBJECTIVE: To develop a simple, rapid and cheap catalytic method for methoxylation of aryl halides for late-stage functionalization and demonstrate its utility in isotopic labelling. RESULTS: A ligand-free, microwave-assisted method for methoxylation of aryl halides using copper(II) hydroxide as catalyst has been explored. The new method is simple and cheap, afforded synthetically useful yields in some cases, but does not seem to give generally higher yields in more substituted systems. The viability of isotopic labelling using the method has been demonstrated by 13C-incorporation at the methoxy group.

Source: BMC Research Notes

DOI: 10.1186/s13104-026-07720-x

Authors: Karoline Nordli, Xavier Jouffroy, Meda Surdokaitė, Melina Flakowski, Anna Walter, Jørn H. Hansen

Institution: UiT The Arctic University of Norway

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,690

Funder: Universitetet i Tromsø